International Classification of Retinoblastoma (ICRB)

 

Table : International Classification of Retinoblastoma (ICRB)

A	Small intraretinal tumors (< 3mm) away from foveola and disc.
B	Tumors > 3mm, macular or juxtapapillary location, or with subretinal fluid.
C	Tumor with focal subretinal or vitreous seeding within 3mm of tumor.
D	Tumor with diffuse subretinal or vitreous seeding > 3mm from tumor.
E	Extensive retinoblastoma occupying >50% of the globe with or without neovascular glaucoma, hemorrhage, extension of tumor to optic nerve or anterior chamber.

Group A	Small tumors <3 mm confined to retina, >3 mm from fovea, >1.5 mm from optic disc
Group B	Tumors >3 mm confined to retina at any location, with SRF <6 mm from tumor margin
Group C	Localized vitreous or subretinal seeding <6 mm from tumor margin or total from multiple sites <6 mm
Group D	Diffuse vitreous or subretinal seeding >6 mm from tumor margin or total from multiple sites >6 mm.  SRF >6 mm from tumor margin
Group E	No visual potential or presence of:  – Tumor in anterior segment  – Tumor in ciliary body  – Neovascular glaucoma  – Vitreous hemorrhage or hyphema  – Phthisical or prephthisical eye  – Orbital cellulitis-like presentation

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