Eponyms and their characteristics

 Eponyms and their characteristics.

Eponym	Location	Description / context / pathophysiology	Relevance
Hudson-Stahli line	Cornea	Brown-green, horizontal line. Middle to inferior 1/3 cornea. Significance: iron deposition, usually with age. Enhanced by chloroquine or hydroxychloroquine.	Not usually visually significant
Waring line	Cornea	Stellate corneal epithelial iron deposition. After radial keratotomy (RK). Present in up to 80% of RK eyes.	Not usually visually significant
Khodadoust line	Cornea	Line on the corneal endothelium in an eye with a corneal graft. Keratoplasty / corneal graft surgery. Mononuclear cells / keratic precipitates accumulating on the corneal endothelium.	Corneal graft endothelial cell rejection

Eponym	Location	Description / context / pathophysiology	Relevance
Paton’s lines	Retina / optic disc	Vertical, circumferential retinal folds especially temporal to the optic disc. On direct ophthalmoscopy they are better visualised when the light on ophthalmoscope is moved back and forth. Optic nerve head swelling, protrusion and eventual corrugation of the retina. Blockage of the axoplasmic transport at the lamina cribrosa.	Optic disc swelling
Sampaolesi’s line	Drainage angles	Pigment deposition along Schwalbe’s line.	Pseudoexfoliation, pigment dispersion syndrome, iris melanoma, trauma
Scheie’s line	Lens	Also see Zentmayer ring. Pigment accumulated at the zonular attachments to the lens. Although some report it as pigment on peripheral posterior lens capsule.	Pigment dispersion syndrome
Arlt’s line	Conjunctiva	Horizontal scarring of the upper tarsal conjunctiva at the junction of the anterior one third and posterior two thirds of the conjunctiva.	Typically seen in trachoma. Chronic inflammation of tarsal conjunctiva
Stocker’s line	Cornea	Yellow or brown deposition in epithelium. Iron deposition can be seen adjacent to the leading edge of pterygium.	Pterygium
White lines of Vogt	Retina	Sheathed or sclerosed vessels in lattice degeneration.	Lattice degeneration
Vogt striae	Cornea	Vertical stromal / Descemet’s membrane lines. Stress lines due to stretching and thinning. Disappear with globe pressure.	Keratoconus
Haab striae	Cornea	Horizontal or concentric breaks in Descemet’s membrane. Similar to posterior polymorphous dystrophy (PPMD). However on histopathology: the edge of Haab’s striae are thickened, curled, with the area between the edge being smooth and thin. This helps differentiate from PPMD.	Congenital glaucoma
Ohngren’s line	Orbit	An x-ray description from 1930. Delineates the limits of resectability of maxillary sinus tumours. If superoposterior it is more likely to invade orbit, ethmoids and paterygopalatine fossa.	Its use is less certain due to a difference in surgical techniques and treatments
Ferry line	Cornea	Corneal epithelial line at the edge of trabeculectomy blebs. Iron deposition.	No visual significance
Ehrlich-Turck line	Cornea	Linear deposition of KPs on corneal endothelium. Uveitis.	Uveitis
Schwalbe’s line	Drainage angles	Clinical: gonioscopic view of the drainage angles. Delineates anterior edge of trabeculum and termination of Descemet’s membrane.	Recognition, last to angle structure to disappear in narrow angles
Siegrist streaks	Choroid	Hyper-pigmented flecks that are arranged in a linear fashion along the choroidal blood vessels. Hypertensive choroidopathy. Fidrinoid necrosis.	Hypertension Giant cell arteritis
Linear naevus sebaceous of Jadassohn	Periorbit	A congenital hairless plaque that is usually found on the scalp, face or neck.	Schimmelpenning syndrome: triad of: sebaceous nevi, seizures and learning difficulties. Ocular: coloboma, choristomas, e.g. posterior scleral cartilage
Kayes dots	Cornea	Subepithelial infiltrates seen in corneal graft rejection. Could be an elevated line.	Corneal graft rejection
Gunn’s dots	Retina	These are visible reflections of the internal limiting membrane, created by the footplate of the Muller cells. Described in 1918. Note Marcus Gunn was using an ophthalmoscope based on a mirror and a solid flame as an illuminating source to find them.	Significance: Uncertain. Described as a cause for photosensitivity
Horner-Trantas dots	Cornea	Gelatinous dots at the corneal limbus. Chalky collections of eosinophils at limbus.	Vernal Keratoconjunctivitis
Mittendorf’s dot	Lens	Whitish spot (on direct illumination) at posterior lens surface. Black in retroillumination. Usually nasal / inferonasal. Embryological remnant of the hyaloid artery.	Associated posterior polar cataract, care as associated with posterior capsule (PC) rupture risk during hydrodissection

Eponym	Location	Description / context / pathophysiology	Relevance
Bitot’s spot	Conjunctiva	White, foamy area (oval / triangular / irregular in shape) on conjunctiva. Conju quamous metaplasia of bulbar conjunctiva with keratin layer.	Vitamin A deficiency Xerophthalmia
Elschnig spots	Choroid	Hyperpigmented patches in the choroid surrounded by a ring of hypopigmentation. Choriocapillaris hypoperfusion.	Hypertension
Fuchs spot	Retina	Pigmented macular lesion. Significance: retinal pigment epithelium (RPE) hyperplasia / degeneration. Forster-Fuchs’ retinal spot: subretinal neovascularisation.	Pathological myopia
Brushfield spot	Iris	White, grey spots in peripheral iris. Iris stromal hyperplasia and surrounding hypoplasia.	Down’s syndrome present in around 78%
Roth’s spots	Retina	Haemorrhages with white centre. Platelet and fibrin thrombus at the centre of a ruptured capillary network. Also: immune complex mediated vasculitis.	Numerous e.g.: •   Subacute bacterial endocarditis •   Leukemias •   Anaemia •   Anoxia •   Carbon monoxide poisoning •   Eye decompression
Koplik’s spot	Conjunctiva	Occur on the conjunctiva and resemble specks of sand surrounded by a red areola. Also curuncle lesion and semilunar fold (Hirschberg’s sign).	Measles
Fischer-Khunt spot	Sclera	Blue grey plaque anterior to horizontal recti insertions. Senile scleral plaque. Area of hyalinised sclera.	Seen in old age
Krachmer spots	Cornea	Sub-epithelial opacities similar in appearance to adenovirus keratitis. Present Bowman’s layer. Note: Stromal swelling can coincide leading to some calling it a stromal rejection.	Corneal graft epithelial rejection
Kayser-Fleischer ring	Cornea	Deposition in peripheral cornea with a gold / brown / yellow / green hue. Starts superior, then inferior and finally circumferential. Copper deposition in Descemet’s membrane.	Wilson’s disease present in about 95% with neurological Wilson’s. Whilst around 65% in those with hepatic disease
Fleischer’s ring	Cornea	Best seen with cobalt blue filter. Basal epithelial iron deposition around base of cone.	Keratoconus
Vossius ring	Lens	Iris pigment imprinting on the anterior lens capsule. Pigment after trauma. Note force has to be high enough to flatten cornea.	Significant traumatic force likely
Wessley ring	Cornea	At the level of the stroma. Corneal viral antigen precipitate. Type 3 immune response involving antigen-antibody complex formation.	Not specific as numerous causes possible e.g. trauma, infectious vs. sterile causes. Microbial keratitis important cause. Beware in contact lens wearers, etc.
Soemmering’s ring	Lens	Doughnut shaped ring at capsule. In pseudophakia and also reported in Aphakia or ocular trauma. Cortical regeneration and transformation into Elschnig pearls and an element of equatorial epithelial proliferation.	Incomplete cortex removal Trauma
Zentmayer ring	Lens	See Scheie line. Pigment accumulated at the zonular attachments to the lens.	Pigment dispersion syndrome
Coat’s white ring	Cornea	Granular, oval ring, patient asymptomatic. Iron deposition at the level of Bowman’s layer. Usually associated with a previous corneal foreign body.	Not usually visually significant
Amsler’s Sign	Anterior chamber	A haemorrhage opposite a paracentesis site due to rupturing of small angle vessels in Fuchs. Heterochromic Iridocyclitis.	Can cause problems during intraocular surgery